Apoptosis

The eleventh annual Forbeck Forum was held November 2-4, 1995 at Moss Creek in Hilton Head, South Carolina.  Attending were eleven invited participants from around the world, as well as members of the Foundation's Scientific Advisory Board.  The subject of the meeting was programmed (apoptotic) cell death in the development and treatment of cancers.

The numbers of cells in a tissue, whether normal or cancerous, depends upon the relationship between the rate of cell proliferation (production) and cell death (cell loss).  In normal tissues, these rates are balanced such that neither overgrowth of the tissue nor regression occur with time.  A fundamental characteristic of cancer cells is that, unlike their normal counterparts, their rate of cell proliferation exceeds their rate of death, thus producing continuous net growth of the cancer.  Therefore, malignant conversion results in a dysfunction in the regulation of cell proliferation and / or cell death.