Second Malignancies

The XIIIth Forbeck Research Foundation Forum focused on the observation that secondary cancers can occur in patients, after they have been treated for their original malignancy.  This effect is particularly marked following the administration of particular combinations of cytotoxic drugs.  Most second malignancies are leukemias, and one of the groups of drugs known to cause these cancers is called "topoisomerase II inhibitors".  While the toxicity of these drugs is well recognized, they often form essential components of drug regiments used for the successful treatment of cancer.