Molecular Targets in Pediatric Malignancies

Several themes were developed during the course of the symposium. These included the concept of “oncogene addiction” in which a cancer cell becomes “addicted” to it’s mutant oncogene, rendering it susceptible to induction of cell death by oncogene inhibitors. The role of the microenvironment in supporting tumor cell growth, and as a target for therapy was discussed. In addition to targeting of kinases in cancer, such as BCR-ABL, the potential for targeting the apoptotic machinery of cancer cells was present- ed by several investigators.