Immunotherapy and Breaking Tolerance

The 2008 Forbeck Symposium focused on new developments in cancer immunotherapy. Recent findings in tumor immunology have provided a clearer understanding of the complex interaction between the host immune system and cancer. Significant progress has been made in elucidating the function and regulation of immune cells, in identifying molecules that are expressed by tumor cells and can be targeted for immune-based therapy, and in understanding the mechanisms by which tolerance to self-antigens is maintained. These insights have resulted in a significant transformation in the field of tumor immunology over the past several years, and led to the development of novel therapies that are now yielding encouraging results in a subset of human cancers.