The 2015 Forum was focused on Cancer Immunotherapy. Major topics of the forum included (i) cellular therapies using antigen specific and gene-modification T cells for targeting leukemia and solid tumors; (ii) overcoming hurdles and barriers with regard to immunogenicity, immune escape, and the role of tumor microenvironment; (iii) vaccine strategies and antigen presentation; (iv) the role of immune cells in allogeneic transplantation; and (v) current antibody/combination approaches for the treatment of pediatric malignancies. During the past decade, major advances have been made in improving the efficacy of these modalities and regulatory hurdles have been taken. Nevertheless, there is still a long way to go to fully exploit potential of immunotherapeutic strategies to improve the cure of children and adolescents with malignancies. This forum supported new collaborations and insights for further translational and clinical immunotherapy studies.